All Wanda has ever known is her friendly little neighborhood in Queens. As an infant, after her parents died, she was adopted into a family where her doting Aunt May and Uncle Ben would always be at the breakfast table. One that includes her idiot brother, Peter Parker, who thinks hiding a spider bite, joining a secret fight club, and becoming a super hero are somehow good ideas.

When Wanda's own powers emerge, blood, chaos, and suspicion follow in their wake. But as she learns to harness her power under the guidance of Doctor Strange, Peter is standing beside her in the Sanctum Sanctorum. And as they try to protect New York City, the Parker siblings learn that with great powers, there must also come great responsibilities--and greater losses.

Reeling from tragedy, Wanda finds herself truly alone for the first time in her life. Peter is lost to his own grief, and so she must forge ahead on her own. But on her first solo outing, she runs into a mysterious speedster--a man named Pietro. And everything she has ever known shatters like glass.

Faced with unbelievable truths, Wanda is forced to choose between the life she knows and the life she could have.