In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

Nikaido and Natsuki comfort Caiman after he is forced to confront some dark truths about his origins. Meanwhile, Professor Kasukabe goes grave digging with Shin and Noi in an attempt to unravel the mysteries surrounding a strange wax doll they have encountered. As Dokuga's gang of Cross-Eyes desperately try to cover their involvement in a murder, Asu finds himself in serious trouble with his fellow Devils. Hold on tight for the next installment of Dorohedoro!