Jimmy Kudo, the son of a world-renowned mystery writer, is a high school detective who has cracked the most baffling of cases. One day while on a date with his childhood friend Rachel Moore, Jimmy observes a pair of men in black involved in some shady business. The men capture Jimmy and give him a poisonous substance to rub out their witness. But instead of killing him, it turns him into a little kid! Jimmy takes on the pseudonym Conan Edogawa and continues to solve all the difficult cases that come his way. All the while, he's looking for the men in black and the mysterious organization they're with in order to find a cure for his miniature malady.

Bloody murder is committed at a museum, reproducing a scene from a gruesome painting.

Later, the men in black are back! Will Conan be able to come any closer to getting his old body back?

Also, Conan's friends from grade school find a treasure map--but will it only lead them to a trove of trouble?