In "The Supergirl from Krypton," Kara lands on Earth and discovers that she possesses all the same powers as her cousin, Superman. Inspired by her famous kin, Kara adopts a secret identity and uses her powers to help those in need.

This inaugural volume contains Supergirl's appearances from 1959 to 1962 in the pages of ACTION COMICS #252-288, ADVENTURE COMICS #278, SUPERMAN #139-140 and #144, SUPERBOY #80, SUPERMAN'S GIRL FRIEND LOIS LANE #14 and #20, and SUPERMAN'S PAL, JIMMY OLSEN #40, #46, #51, and #57.