In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

On their journey through a hellish landscape, Caiman and Nikaido finally get intimate...sort of! Assisted (?) by Chidaruma, the Professor, Asu and more, the pair continue their quest to unravel the mystery that is Caiman, and what it will reveal for the future of the Sorcererss world and the poor souls of the Hole.