When exhausted workaholic apothecary Colette jumps into a well, instead of dying she finds herself caring for a new patient: Hades, Lord of the Dead. As Colette goes back and forth between her world and the underworld, new patients of every kind arrive daily!

Colette meets Hades, a fellow workaholic, while he is ill in bed with a rash and fever. After treating his condition, she learns about the work he does and what drives him, in turn renewing her sense of purpose as an apothecary. Colette is sent back to her own world, but is this the last she will see of Hades?