Six strangers arrive at the home of preeminent puzzle master Alexei Vasiliev for the reading of his will. Among them are the deceased's widow, who'd already begun divorce proceedings, a virologist troubled by actions in his past, and a convicted murderer on day leave.

The choice is simple: leave with nothing, or continue in the hope of solving the six interconnecting escape rooms with this house.

Once there, the participants soon discover Puzzle House is far deadlier than it appears, and that making their way through the rooms may be a matter of life and death. Someone is watching their every move, toying with them, turning them against each other. With their lives on the line, they are forced to wonder: Is it all a deadly game created by a gleeful sadist, or something far more sinister?