It is 1934, and New York City is in the icy grip of the Great Depression. With enormous compassion, Dr. James Delaney tends to his hurt, sick, and poor neighbors, who include gangsters, day laborers, prostitutes, and housewives. If they can't pay, he treats them anyway.

But in his own life, Delaney is emotionally numb, haunted by the slaughters of the Great War. His only daughter has left for Mexico, and his wife Molly vanished months before, leaving him to wonder if she is alive or dead. Then, on a snowy New Year's Day, the doctor returns home to find his three-year-old grandson on his doorstep, left by his mother in Delaney's care. Coping with this unexpected arrival, Delaney hires Rose, a tough, decent Sicilian woman with a secret in her past. Slowly, as Rose and the boy begin to care for the good doctor, the numbness in Delaney begins to melt.