Once More, With Feeling follows Jane, an artist navigating her closest relationships while fixating on her own perceived failures and self-imposed isolation. When Jane receives a student grant to attend a workshop in London, England, she sees the opportunity to leave her tedious life behind and start anew, bringing along her new friend Kitty, who Jane will not admit she has little in common with other than a shared appreciation for boxed wine and various other drugs.

In London, Jane struggles to improve both her craft and her mindset while Kitty thrives, and a once exciting trip abroad transforms the already uneven dynamic of their friendship, leaving Jane feeling more withdrawn than ever. As her increasingly destructive behaviour gets in the way of her artistic ambitions, her most important relationships--those with Kitty, her absent lover Richard and a discredited therapist named Anna--begin to deteriorate as Jane starts to examine her growing dependence on substances.

Darkly funny, piercing and tender, Once More, With Feeling is a portrait of a detached young woman trapped in the perils of self-loathing and addiction, who is searching for originality in an age of profound social disconnection and anxiety.