In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.

The hunters become the hunted when the Elric brothers and Prince Lin set a trap for the homunculus with the insatiable appetite--Gluttony! On another front, state politics are shaken up when a horrifying truth about Führer President King Bradley is revealed--and Colonel Roy Mustang is right there to capitalize on the situation.