In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Seven years have passed since the devastating battle in Pieta, and now a new generation of warriors carries on the fight against the Awakened Ones. However, the mystery of Clare's fate, and that of her comrades, resurfaces after a surprising discovery made by a young Claymore.