In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Rebel Claymores, the Organization that created them, and a host of reanimated top-level warriors clash with savage intensity. The Claymores' demonic impulses are provoked, threatening to destroy their human consciousnesses. Meanwhile, Hysteria, animated by blind vengeance, grows stronger with each attack against her. Is it possible that the rebels will be defeated by their long-dead comrades?