In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Three battles unfold around the holy city of Rabona as demonic forces seek to destroy one another, the rebel Claymores and the city itself. Seemingly intent on devouring all life, monsters of unprecedented strength rage on as the rebels struggle to contain them. Could the cause of this rage lie in a distant childhood memory?