"Bloody" Mary, a vampire with a death wish, has spent the past 400 years chasing down a modern-day exorcist named Maria who is thought to have inherited "The Blood of Maria" and is the only one who can kill Mary. To Mary's dismay, Maria doesn't know how to kill vampires. Desperate to die, Mary agrees to become Maria's bodyguard until Maria can find a way to kill him.

Maria's father, Yusei, was killed by vampires--and it was Maria's own fault. Haunted by guilt, he sealed away the memory. That is, until he remembers the face of the murderous vampire...and it looks just like Mary's! On a mission for answers, Maria comes to the kidnapped Mary's rescue, but he finds someone else within Mary...