2Why did the Pilgrims and other settlers come to North America? How did American Indians react to white settlers on their land? How was North America changed by the colonists? The colonization of the New World led to major changes for both European colonists and the native peoples who already lived there. Using an inquiry-based approach, primary sources, and quick-reference infographics, readers will learn all about the historic changes that took place in the land and various people's lives at the beginning of Colonial America.