Why do people and groups ignore, deny, and resist knowledge about society's many problems? In a world of 'alternative facts' and 'fake news', which some believe could be remedied by 'factfulness', the question has never been more pressing. After years of ideologically polarised debates on this topic, this book seeks to further advance our understanding of the phenomenon of knowledge resistance by integrating insights from the social, economic and evolutionary sciences. It identifies simplistic views in public and scholarly debates about what facts, knowledge and human motivations are and what 'rational' use of information actually means. The examples presented include controversies about nature-nurture, climate change, gender roles, vaccination, genetically modified food and artificial intelligence. Drawing on cutting-edge scholarship as well as personal experiences of culture clashes, Knowledge resistance is aimed at the general public as well as students and scholars interested in the interface of human motivation and the urgent social problems we face today.