Italy, 1911. Pietro's life on the family vineyard is idyllic. He has at last captured the melody of the grape harvest on his clarinet and can't wait to share his composition with his grandfather, but before he can play, news arrives of a deadly disease sweeping the countryside. They have no choice but to burn the vineyard to stop its spread. The loss is too much for Pietro's grandfather, and by morning Pietro has lost two of the most precious things in his life-his grandfather and the vineyard. All he has left is his music, but a disastrous performance at his grandfather's funeral suggests that music, too, is now beyond his reach.

Adrift with grief, Pietro seeks a new start in America. He goes to work in a Pennsylvania coal mine where his musician's hands blister and his days are spent in the muffled silence of underground.

When the beautiful voice and gentle heart of a friend's wife stirs a new song in him, Pietro at last encounters a glimmer of hope. From a respectful distance and without catching the attention of her husband, Pietro draws on Assunta for inspiration and soon his gift for music returns. But when grief strikes in Assunta's life, Pietro is to blame. When Prohibition steals Pietro's last pleasure, he has to do something before Assunta's grief consumes them both.

Inspired by true events, From Ashes to Song is a story of unconventional love, hope, and the extraordinary gifts brought to America by ordinary people in the great wave of immigration.