Jeremiah Staggart, a Confederate soldier, discovers while on leave in 1863 that Union soldiers have murdered his family and burned his farm in Tennessee. Because he could not save his family, Staggart succumbs to a paralyzing guilt that leads him to the edge of madness. After the horrific battles of Chickamauga and Chattanooga he deserts and, after working in Omaha for three years, arrives in Green River, Wyoming in August, 1866. There he meets Sheriff James Talbot, another Civil War veteran, who is trying to maintain peace between cattle baron Brent Tompkin and a band of Southern Cheyenne led by Chief Running Bear. Like many Cheyenne chiefs, Running Bear was infuriated by the terrible slaughter of Indians at Sand Creek, Colorado in 1864, and he has moved his tribe to the canyons northeast of Green River.

Sheriff Talbot employs an Irish half-breed, Johnny Redfeather, also a Civil War veteran, in his efforts to maintain peace in and around Green River. When Jeremiah goes to work for Tompkin's cattle business, he becomes deeply involved in the ensuing conflict. In his deepening delusion and search for redemption, Jeremiah, believing he is following his Biblical namesake, becomes obsessed with saving an Indian woman and her child whom he comes to believe are his lost wife and child. In the final battle at Greens Canyon the fate of Running Bear's tribe, Johnny Redfeather, and Jeremiah's frantic search for redemption and his lost family collide. Includes Readers Guide.