Virtue explores the vulnerability and randomness of human existence through the lives of Tom and Hannah Holder, each of whom are grappling with midlife crises. Tom's life unravels as he fends off attacks on his career, faces his estranged, cancer-stricken father and confronts a dark, hidden past. Hannah-sick of being a stay-at-home and fearing for her troubled teenagers-chooses to reclaim her life and rescue her children from an increasingly toxic situation. Will their marriage survive the most tumultuous year of their adult lives?