After almost losing his life in a boating accident, Robert Merrick is inspired by the life of Dr. Hudson, a kindly and compassionate fellow who spent his career saving lives. Hudson perishes at the very start of the novel, and his loss is felt throughout the local community. Robert uses a book entitled Dr. Hudson's Secret Journal to gain the secret to the late physician's success; over the course of years he successfully studies medicine and gains his medical license.

Later in the book we are introduced to Mrs. Hudson - the doctor's widow - and her daughter Joyce. The pair are impressed by Bobby's dedication to gaining a medical license, as a way of honoring the deceased Dr. Hudson's memory.

Magnificent Obsession was first adapted for the silver screen in 1935. It returned to the public eye in the 1950s, when a full color Hollywood adaptation starring Jane Wyman and Rock Hudson hit theaters.