Comatose follows the lives of four strangers who are trying to cheat death. On the surface, these people - a famous Hollywood director suffering from terminal brain cancer, a budding scientist in Artificial Intelligence whose honeymoon tragically ended with a freak plane accident, an angry orphan who lost her closest family to a tragic motorcycle accident, and the leading medical expert in treating comatose patients - appear to have nothing in common.

However, once they independently uncover a link between lucid dreaming and comas, their lives start to intersect. They uncover astounding opportunities to ease individual suffering and pain as they crisscross different time periods and distant locations in their odysseys. The competing factions careen forward into a life-threatening race for survival and supremacy, ultimately leading to an exciting conclusion that explains why we really dream.